IMR Press / FBE / Volume 5 / Issue 3 / DOI: 10.2741/E674

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Monitoring molecules in neuroscience: historical overview and current advancements

Show Less
1 Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden

*Author to whom correspondence should be addressed.

Academic Editor: R. N. Addy

Front. Biosci. (Elite Ed) 2013, 5(3), 947–954;
Published: 1 June 2013
(This article belongs to the Special Issue Subsecond dopamine signaling in the mammalian brain)

During the last 50 years, the minimally invasive techniques for monitoring brain chemistry in vivo have significantly contributed to our current understanding of chemical neurotransmission in relation to behavior, as well as, to neuropathology and neuropharmacology of CNS disorders. This article provides a short historical overview of implantable devices including voltammetric electrodes, biosensors, microdialysis and related analytical techniques developed for monitoring and sampling brain chemistry in experimental disease models. A special emphasis is given to dopamine, which besides its important role as a neurotransmitter, could be readily detected by electrochemical techniques. Today, about 70% of all published papers applying voltammetry in the brain refer to dopamine monitoring; the corresponding percentage of brain microdialysis papers referring to dopamine is 41%.

Oxygen Electrode
Back to top