IMR Press / FBE / Volume 5 / Issue 2 / DOI: 10.2741/E655

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Association of VEGF +405G>C polymorphism with endometriosis

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1 M.Sc. Research Scholar, MHRT Hospital and Research Centre, Owaisi Hospital and Research Centrre Hyderabad
2 M.D., A.I.I.M.S, Delhi, F.R.C.O.G., London, Chief Fertility Specialist, Research Director of MHRT-Hospital and Research Centre, Professor and Head Owaisi Hospital, Deccan College of Medical Sciences
3 C.T.O. of Bioserve Biotechnologies India Pvt Ltd, Hyderabad, 500076
4 M.Sc, M.Phil. Scientist R and D, Bioserve Biotechnologies India Pvt Ltd, Hyderabad, 500076
5 Head, Department of Genetics, Osmania University, Hyderabad

*Author to whom correspondence should be addressed.

Academic Editor: Roya Rozati

Front. Biosci. (Elite Ed) 2013, 5(2), 748–754; https://doi.org/10.2741/E655
Published: 1 January 2013
(This article belongs to the Special Issue Frontiers in reproductive biomedicine)
Abstract

The present study was designed to explore the association between the SNP +405G>C of the VEGF gene with the risk of endometriosis, and endometriosis associated with adenomyosis and chocolate cysts. Following extraction of genomic DNA, genotyping of the +405 G>C polymorphisms of the VEGF gene was performed by PCR - RFLP analysis. The genotype (X2 =21.713, 2 df, P = < 0.0001) and allele (X2 =10.697, 1 df, P = 0.0011) frequencies of endometriosis patients were significantly different from those of the control women. The genotype and allele frequencies significantly differed in all the clinical subgroups of endometriosis patients. The significant differences in allele frequencies were the result of an increased proportion of homozygote GG genotype carriers. No significant difference was observed between the clinical subgroups with respect to the genotype and allele frequencies of the VEGF +405G>C polymorphism. These findings suggest that the VEGF +405 G>C polymorphism is associated with the risk of endometriosis, and endometriosis associated with adenomyosis and chocolate cysts.

Keywords
Angiogenesis
Endometriosis
Polymorphism
VEGF
Laparoscopy
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