IMR Press / FBE / Volume 5 / Issue 2 / DOI: 10.2741/E654

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Tissue-specific implications of mitochondrial alterations in aging

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1 Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, Zhejiang 325035, China
2 Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA

*Author to whom correspondence should be addressed.

Academic Editor: Yidong Bai

Front. Biosci. (Elite Ed) 2013, 5(2), 734–747;
Published: 1 January 2013
(This article belongs to the Special Issue Mitochondrial dysfunction and mitochondrial mutations in aging)

Aging is a multifactorial process during which physiological alterations occur in all tissues. A decline in mitochondrial function plays an important role in the process of aging and in aging-associated diseases. The mitochondrial genome encodes 13 essential subunits of protein complexes belonging to the oxidative phosphorylation system, while most of the mitochondriarelated genes are encoded by the nuclear genome. Coordination between the nucleus and mitochondria is crucial for the regulation of mitochondrial biogenesis and function. In this review, we will discuss aging-related mitochondrial dysfunction in various tissues and its implication in aging-related diseases and the aging process.

Aging- associated diseases
mtDNA mutation
Mitochondrial regulation
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