IMR Press / FBE / Volume 5 / Issue 2 / DOI: 10.2741/E653

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Perinatal exposure to diethyl-hexyl-phthalate induces obesity in mice

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1 Reproductive and Genetic Center, National Research Institute for Family Planning, No. 12, Dahuisi Rd., Beijing 100081, PR China
2 Graduate School, Peking Union Medical College, No. 1, Shuaifuyuan Rd., Beijing 100730, PR China
3 National Quality Supervision and Test Center for Grain and Oil, No. 46, Xihongmen Rd., Beijing 100162, PR China

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2013, 5(2), 725–733; https://doi.org/10.2741/E653
Published: 1 January 2013
Abstract

The environmental obesogen hypothesis proposes that exposure to endocrine disruptors during developmental “window” contributes to adipogenesis and the development of obesity. Implication of environmental endocrine disruptor such as diethyl-hexyl-phthalate (DEHP) on adipose tissue development has been poorly investigated. Here, we evaluated the effects of DEHP on adipocyte differentiation in vitro and in vivo, and explored potential mechanism involved in its action. DEHP had no effect on adipocyte differentiation in the murine 3T3-L1 cell model, whereas DEHP induced the expression of transcriptional factors peroxisome proliferator-activated receptor (PPAR) gamma, CCAAT/enhancer-binding protein (C/EBP) alpha and sterol regulatory element binding factor 1 (Srebf1) as well as downstream target genes required for adipogenesis in vivo. Furthermore, perinatal exposure to DEHP had an impact on filial adipogenesis. Body weight, adipose tissue deposition, serum lipids and glucose levels were significantly elevated in offspring at postnatal day (PND) 60. Therefore, these results suggested that perinatal exposure to DEHP might be expected to increase the incidence of obesity in offspring and could act as a potential chemical stressor for obesity and obesity-related disorders.

Keywords
Diethyl-hexyl-phthalate
Perinatal exposure
Peroxisome proliferator-activated receptor gamma
Adipogenesis
Obesity
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