IMR Press / FBE / Volume 5 / Issue 2 / DOI: 10.2741/E652

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Effects of early endometriosis on IVF-ET outcomes

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1 Department of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan

*Author to whom correspondence should be addressed.


Front. Biosci. (Elite Ed) 2013, 5(2), 720–724;
Published: 1 January 2013

There have been very few reports on the outcomes of in vitro fertilization and embryo transfer (IVF- ET) in women with stage I/II endometriosis. The objective of this study was to investigate IVF-ET outcomes in women with early-stage endometriosis. We enrolled 35 women less than 40 years with unexplained infertility who underwent IVF-ET into the study. We compared 18 women with stage I/II endometriosis according to the revised American Society for Reproductive Medicine classification for endometriosis, who underwent 39 IVF-ET cycles [En (+) group] with 17 women without endometriosis who underwent 41 IVF-ET cycles [En (−) group]. Higher requirements of total gonadotropin, a lower percentage of high-quality embryos of all fertilized eggs (9.0% vs. 16.3%), a relatively lower pregnancy rate (33.3% vs. 41.5%), and a lower live birth rate (25.6% vs. 34.1%) were observed in the En (+) group. Although no significant effect on IVF-ET outcome was observed, ovarian response may be decreased in women with stage I/II endometriosis. Considering the decreased number of high-quality embryos in the En (+) group, stage I/II endometriosis may have detrimental effects on embryo quality.

Early endometriosis
In vitro fertilization and embryo transfer
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