IMR Press / FBE / Volume 5 / Issue 2 / DOI: 10.2741/E634

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Gray matter SWI-filtered phase and atrophy are linked to disability in MS

Show Less
1 Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
2 The Jacobs Neurological Institute, University at Buffalo, Buffalo, NY, USA, 3Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, USA

*Author to whom correspondence should be addressed.

Academic Editor: Alireza Minagar

Front. Biosci. (Elite Ed) 2013, 5(2), 525–532; https://doi.org/10.2741/E634
Published: 1 January 2013
(This article belongs to the Special Issue Inflammatory disorders of the nervous system)
Abstract

The association between clinical outcomes and abnormal susceptibility-weighted imaging (SWI)-filtered phase, indicative of increased iron content, as well as atrophy, was investigated in the subcortical deep-gray matter (SDGM) of multiple sclerosis (MS) patients. 149 relapsing-remitting (RR) and 61 secondary-progressive (SP) MS patients underwent SWI on a 3T scanner. Mean phase of the abnormal phase tissue (MP-APT) and normalized volumes were determined for the total and region-specific SDGM structures. In an age- and gender- adjusted regression model, total SDGM volume was the strongest predictor of Expanded Disability Status Scale (EDSS) (beta = -.224, p <.001), followed by total SDGM MP-APT (beta = -.168, p <.019). This model accounted for 30.4% of the variance in EDSS. Only SDGM MP-APT added additional variance in predicting EDSS, compared to conventional MRI metrics. Caudate and red nucleus MP-APT and amygdala volume were associated with EDSS. Our findings suggest that disability in MS patients is associated better with SDGM pathology, as indicated by increased iron content and atrophy, than with lesion burden or white matter and cortical volumes.

Keywords
Multiple sclerosis
Abnormal phase
Iron deposition
Susceptibility-weighted imaging filtered phase
Brain atrophy
Disability
Share
Back to top