IMR Press / FBE / Volume 5 / Issue 2 / DOI: 10.2741/E632

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Cell-penetrating peptides: from cell cultures to in vivo applications

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1 Department of Neurochemistry, the Arrhenius Laboratories for Natural Sciences, Stockholm University, Svante Arrhenius vag 21A, SE-10691 Stockholm, Sweden

*Author to whom correspondence should be addressed.


Front. Biosci. (Elite Ed) 2013, 5(2), 509–516;
Published: 1 January 2013

The field of gene therapy is starting to move towards clinical applications but is currently limited by the lack of efficient delivery systems. Cell-penetrating peptides provide a means of cellular delivery for gene therapy applications as well as delivery of traditional drugs. Using cell-penetrating peptides a range of different cargos have been successfully delivered into a number of cell types, in vitro as well as in vivo. In this review we discuss uptake mechanisms of different cell-penetrating peptides, with or without cargo. The transition from in vitro to in vivo applications and strategies to increase the bioavailability of cell-penetrating peptides are also discussed.

Cell-penetrating peptides
Drug delivery
Gene therapy
In vivo
Clinical trial
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