IMR Press / FBE / Volume 5 / Issue 2 / DOI: 10.2741/E632

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Cell-penetrating peptides: from cell cultures to in vivo applications

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1 Department of Neurochemistry, the Arrhenius Laboratories for Natural Sciences, Stockholm University, Svante Arrhenius vag 21A, SE-10691 Stockholm, Sweden

*Author to whom correspondence should be addressed.

Academic Editor: Darja Kanduc

Front. Biosci. (Elite Ed) 2013, 5(2), 509–516; https://doi.org/10.2741/E632
Published: 1 January 2013
(This article belongs to the Special Issue Peptides: from basic research to clinical applications)
Abstract

The field of gene therapy is starting to move towards clinical applications but is currently limited by the lack of efficient delivery systems. Cell-penetrating peptides provide a means of cellular delivery for gene therapy applications as well as delivery of traditional drugs. Using cell-penetrating peptides a range of different cargos have been successfully delivered into a number of cell types, in vitro as well as in vivo. In this review we discuss uptake mechanisms of different cell-penetrating peptides, with or without cargo. The transition from in vitro to in vivo applications and strategies to increase the bioavailability of cell-penetrating peptides are also discussed.

Keywords
Cell-penetrating peptides
Drug delivery
Gene therapy
In vivo
Clinical trial
Review
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