IMR Press / FBE / Volume 5 / Issue 2 / DOI: 10.2741/E631

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

(Pro)renin receptor: subcellular localizations and functions

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1 Max-Delbrueck-Center for Molecular Medicine (MDC), Robert-Roessle-Strasse 10, D-13125 Berlin-Buch, Germany
2 INSERM U983, Tour Lavoisier, Hopital Necker-Enfants Malades, 149 rue de Sevres, Paris, France

*Author to whom correspondence should be addressed.

Academic Editor: Fumiaki Suzuki

Front. Biosci. (Elite Ed) 2013, 5(2), 500–508; https://doi.org/10.2741/E631
Published: 1 January 2013
(This article belongs to the Special Issue Handle region peptide and prorenin receptor)
Abstract

Since its first report in 1996, the concept of the so-called (Pro)renin receptor ((P)RR/ATP6ap2) has dramactically evolved from a receptor mediating cellular effects of (pro)renin, to a protein with more basic and potentially essential intracellular functions. Among the arguments urging to reconsider the role of (P)RR was the observation that its localization appears mainly intracellular, although this does not preclude potential functions at the cell surface. However, despite about 10 years of research boosted by the generation of genetically modified animal models, the basic mechanisms of action of this protein at the cellular level remain elusive. This review aims at discussing the functions described for (P)RR in relation to its subcellular localization(s).

Keywords
(Pro)renin receptor
Renin-Angiotensin System
Vacuolar H+- ATPase
Wnt signaling
Autophagy
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