IMR Press / FBE / Volume 5 / Issue 2 / DOI: 10.2741/E628

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

An IL-6 link between obesity and cancer

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1 Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Centre at San Antonio, 15355 Lambda Drive, San Antonio

*Author to whom correspondence should be addressed.

Academic Editor: Jiezhong Chen

Front. Biosci. (Elite Ed) 2013, 5(2), 461–478; https://doi.org/10.2741/E628
Published: 1 January 2013
(This article belongs to the Special Issue Obesity and cancer)
Abstract

Obesity is a growing epidemic all over the world that by virtue of inducation of a chronic, low-grade, and systemic inflammation leads to an increased risk of a number of diseases, including cancer. IL-6 an important cytokine in the increased risk to cancer in obese patients mainly because of its pro-inflammatory activitiy. Some data suggest that IL-6 might increase the risk of certain cancers such as those that originate from breast, liver, prostate, colon, and esophagus. A better understanding of the regulation and role of IL-6 in obesity-associated cancer is required to develop effective therapeutic approaches.

Keywords
Obesity
Cancer
IL-6
Adipose Stromal Cells
Review
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