IMR Press / FBE / Volume 5 / Issue 1 / DOI: 10.2741/E615

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Rapid dopamine dynamics in the accumbens core and shell: Learning and action

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1 Department of Psychology, University of North Carolina, Chapel Hill, NC 27599, USA
2 Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA
3 Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA

*Author to whom correspondence should be addressed.

Academic Editor: R. N. Addy

Front. Biosci. (Elite Ed) 2013, 5(1), 273–288; https://doi.org/10.2741/E615
Published: 1 January 2013
(This article belongs to the Special Issue Subsecond dopamine signaling in the mammalian brain)
Abstract

 

The catecholamine dopamine (DA) has been implicated in a host of neural processes as diverse as schizophrenia, parkinsonism and reward encoding. Importantly, these distinct features of DA function are due in large part to separate neural circuits involving connections arising from different DA-releasing nuclei and projections to separate afferent targets. Emerging data has suggested that this same principle of separate neural circuits may be applicable within structural subregions, such as the core and shell of the nucleus accumbens (NAc). Further, DA may act selectively on smaller ensembles of cells (or, microcircuits) via differential DA receptor density and distinct inputs and outputs of the microcircuits, thus enabling new learning about Pavlovian cues, instrumental responses, subjective reward processing and decision-making. In this review, by taking advantage of studies using subsecond voltammetric techniques in behaving animals to study how rapid changes in DA levels affect behavior, we examine the spatial and temporal features of DA release and how it relates to both normal learning and similarities to pathological learning in the form of addiction.

Keywords
Ventral Striatum
Associative Learning
Catecholamine
Review
Decision Making
Reward
Microcircuit
Error Prediction
Review
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