IMR Press / FBE / Volume 5 / Issue 1 / DOI: 10.2741/E602

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Hematopoietic modulators as potential agents for the treatment of leukemia

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1 Universidade Federal de Sao Paulo, Departamento de Biofisica, Rua Botucatu,862, 2 Andar,CEP: 04023-062, Sao Paulo, SP, Brazil
2 Universidade Federal de Sao Paulo, Departamento de Bioquimica, Rua Tres de Maio, 100, 4 Andar, CEP: 04044-020, Sao Paulo, SP, Brazil
3 Universidade Federal de Sao Paulo, Departamento de Ciencias Biologicas (Campus Diadema) and Departamento de Bioquimica, Campus Sao Paulo, Rua Tres de Maio, 100, 4 Andar, CEP: 04044-020, Sao Paulo, SP, Brazil

*Author to whom correspondence should be addressed.

Academic Editor: Edgar Julian Paredes-Gamero

Front. Biosci. (Elite Ed) 2013, 5(1), 130–140; https://doi.org/10.2741/E602
Published: 1 January 2013
(This article belongs to the Special Issue Hematopoietic regulation and hematology malignancies)
Abstract

Leukemias are the most common malignancy of childhood and have the highest mortality among aging people. Leukemias are a group of blood disorders characterized by an accumulation of leukemic cells in the peripheral blood of patients as a result of disturbances in proliferation and differentiation. Refractory leukemia remains the most common therapeutic challenge. In recent years, the presence of a cancer stem cell population in leukemias has been proposed as a cause for the refractory phenomenon. Insights into the cellular and molecular features of leukemia led to a new point of view in the choice of novel therapeutic agents. New agents for the treatment of this disease should selectively target leukemia stem cells or exhibit higher cytotoxic effects in cancer cells than in normal cells. A special interest is focused on anticancer agents from biological and natural sources that can be used in the treatment of leukemia. This review discusses the characteristics of some of these potential new agents.

Keywords
Leukemia
Leukemia Stem Cell
ATP
Free Radicals
Antimicrobial Peptide
Natural Products
Violacein
Review
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