IMR Press / FBE / Volume 5 / Issue 1 / DOI: 10.2741/E600

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Obesity-associated endometrial and cervical cancers

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1 Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4109, Australia
2 School of Biomedical Science, The University of Queensland, Brisbane, QLD, 4109, Australia
3 Institute of Molecular Virology and Immunology, Wenzhou Medical College, Wenzhou, Zhejiang, 325035, PR China
4 UQ Centre for Clinical Research, The University of Queensland, Herston, Brisbane, QLD, 4029, Australia

*Author to whom correspondence should be addressed.

Academic Editor: Jiezhong Chen

Front. Biosci. (Elite Ed) 2013, 5(1), 109–118; https://doi.org/10.2741/E600
Published: 1 January 2013
(This article belongs to the Special Issue Obesity and cancer)
Abstract

Epidemiological studies have indicated that obesity (body mass index-BMI>30) and overweight (BMI>25) directly associated with risk of many cancers. The association of obesity with cancer risks may be explained by the alterations in the metabolism of endogenous hormones, production of specific proteins and cytokines, adipose related inflammatory reactions, and genetic factors. This review aims to illustrate the link between obesity and occurrence and prognosis of endometrial and cervical cancers. Convincing scientific evidence shows that nutrition and lifestyle factors initiate the development of obesity with excessive adipose tissues, which trigger production of hormones, cytokines and other factors to promote growth of cancer cells. Obese women with either endometrial or cervical cancer, especially in postmenopausal period, have shown a significantly higher mortality. This is mainly due to that the obese women are more vulnerable in cancer occurrence and they are more likely to miss routine cancer screening, putting them at a greater risk for delayed diagnosis of these cancers and deteriorate prognosis. Thus, healthcare providers should pay particular attention to this more vulnerable group of women.

Keywords
Obesity
Endometrial cancer
Cervical cancer
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