IMR Press / FBE / Volume 5 / Issue 1 / DOI: 10.2741/E598

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

The molecular pathogenesis of cholestasis in sepsis

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1 Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University School of Medicine, Richmond, VA, USA

*Author to whom correspondence should be addressed.

Academic Editor: Marcelo Gabriel Roma

Front. Biosci. (Elite Ed) 2013, 5(1), 87–96; https://doi.org/10.2741/E598
Published: 1 January 2013
(This article belongs to the Special Issue Experimental and clinical cholestasis)
Abstract

Sepsis-induced cholestasis is a complication of infection. Infections cause systemic and intrahepatic increase in proinflammatory cytokines which result in impaired bile flow ie. cholestasis. Several other mediators of impairment in bile flow have been identified under conditions of sepsis such as increased nitric oxide production and decreased aquaporin channels. The development of cholestasis may also further worsen inflammation. The molecular basis of normal bile flow and mechanisms of impairment in sepsis are discussed.

Keywords
Cirrhosis
Sepsis
Cholestasis
Bile acids
Bilirubin
Tumor necrosis factor-α
Acute phase reaction
Bacterial translocation
Acute of chronic liver failure
Bilirubinostasis
Review
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