IMR Press / FBE / Volume 5 / Issue 1 / DOI: 10.2741/E597

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Intrinsic toll-like receptor signalling drives regulatory function in B cells

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1 Deutsche Rheuma-Forschungszentrum, a Leibniz institute, Chariteplatz 1, 10117 Berlin, Germany

*Author to whom correspondence should be addressed.

Academic Editor: Isabelle Bekeredjian-Ding

Front. Biosci. (Elite Ed) 2013, 5(1), 78–86; https://doi.org/10.2741/E597
Published: 1 January 2013
(This article belongs to the Special Issue Exploiting toll-like receptors to interfere with the B cell response)
Abstract

B cells can contribute to immunity through production of antibodies, presentation of antigen to T cells, and secretion of cytokines. B cell activation can result in various outcomes for the host. In general B cell responses are beneficial during infections, and deleterious during autoimmune diseases. However, B cells can also limit host defence against pathogens, and protect from autoimmune pathologies. B cells can therefore act both as drivers and as regulators of immunity. Understanding how these opposite functions are mediated shall stimulate the elaboration of novel approaches for manipulating the immune system. B cells might acquire distinct functional properties depending on their mode of activation. Antigen-specific B cell responses require triggering of B cell receptor (BCR) by antigen, and provision of helper signals by T cells. B cells also express various innate immune receptors, and can directly respond to microbial products. Here, we discuss how intrinsic signalling via Toll-like receptors contributes to the suppressive functions of B cells during autoimmune and infectious diseases.

Keywords
B cell
Toll-like receptor
Tolerance
Autoimmunity
Interleukin-10
Infection
Cell therapy
Review
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