IMR Press / FBE / Volume 4 / Issue 8 / DOI: 10.2741/E586

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

An organ system-based approach to prognosis in advanced melanoma

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1 Department of Medicine, Division of Hematology, Mayo Clinic Graduate School of Medicine, 200 First Street SW, Rochester, MN 55905, USA
2 Department of Oncology, Mayo Clinic Graduate School of Medicine, 200 First Street SW, Rochester, MN 55905, USA
3 Department of Obstetrics and Gynecology, Mayo Clinic Graduate School of Medicine, 200 First Street SW, Rochester, MN 55905, USA
4 Department of Immunology, Mayo Clinic Graduate School of Medicine, 200 First Street SW, Rochester, MN 55905, USA
5 Department of Biomedical Statistics and Informatics, Mayo Clinic Graduate School of Medicine, 200 First Street SW, Rochester, MN 55905, USA

*Author to whom correspondence should be addressed.

Academic Editor: Luis Porrata

Front. Biosci. (Elite Ed) 2012, 4(8), 2723–2733; https://doi.org/10.2741/E586
Published: 1 June 2012
(This article belongs to the Special Issue Therapeutic modulation of anti-cancer immunity in humans)
Abstract

Previous models to study the biology of melanoma have focused on individual factors, such as proliferative and invasive capacity, the microenvironment, angiogenesis, or systemic immune dysfunction. However, all of these factors contribute to melanoma progression in concert. One physiologic phenomenon that typifies the coordination of these processes is placental development, characterized by trophoblast proliferation, invasion into decidual tissues, angiogenesis, and transient organ systembased immune evasion. Herein, we explore expression of 34 proteins involved in placentation and determine their association with an established prognostic factor, tumor infiltrating lymphocytes (TILs), in a 118-patient tumor microarray (TMA). Melanoma expression of CD58 and galectin-9 independently predicted for a favorable prognosis. Patients could be categorized into three clusters based upon patterns of protein expression and TILs. Patients in Cluster 2 demonstrated frequent TILs and superior overall survival. Pathway enrichment using MetaCore™ from GeneGo, a Thompson Reuters company, showed that TIMP2 and CD44 were expressed more frequently within Cluster 2 patients, suggesting a potential association with TILs. A subset of melanoma patients appear to lack an organized immune response to the tumor, which portends a poor prognosis.

Keywords
Placenta
Melanoma
Systems biology
CD58
Galectin-9
CD44
TIMP2
B7H1
Tumor infiltrating lymphocytes
Tissue microarray
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