IMR Press / FBE / Volume 4 / Issue 8 / DOI: 10.2741/E583

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Irritable bowel syndrome: the role of gut neuroendocrine peptides

Show Less
1 Section for Gastroenterology, Department of Medicine, Stord Helse-Fonna Hospital, Norway
2 Section for Gastroenterology, Institute of Medicine, Bergen University, Norway
3 Ghrelin Research Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
4 Department of Research, Helse-Fonna, Haugesund, Norway

*Author to whom correspondence should be addressed.

Academic Editor: Darja Kanduc

Front. Biosci. (Elite Ed) 2012, 4(8), 2683–2700; https://doi.org/10.2741/E583
Published: 1 June 2012
(This article belongs to the Special Issue Peptides: from basic research to clinical applications)
Abstract

Irritable bowel syndrome (IBS) is a common chronic disorder with a prevalence ranging from 5 to 10 % of the world's population. This condition is characterised by abdominal discomfort or pain, altered bowel habits, and often bloating and abdominal distension. IBS reduces quality of life in the same degree of impairment as major chronic diseases such as congestive heart failure and diabetes and the economic burden on the health care system and society is high. Abnormalities have been reported in the neuroendocrine peptides/amines of the stomach, small- and large intestine in patients with IBS. These abnormalities would cause disturbances in digestion, gastrointestinal motility and visceral hypersensitivity, which have been reported in patients with IBS. These abnormalities seem to contribute to the symptom development and appear to play a central role in the pathogenesis of IBS. Neuroendocrine peptides/amines are potential tools in the treatment and diagnosis of IBS. In particular, the cell density of duodenal chromogranin A expressing cells appears to be a good histopathological marker for the diagnosis of IBS with high sensitivity and specificity.

Keywords
Diagnosis
Diet
Cholecystokinin
IBS
Gut hormones
Pathogenesis
Serotonin
Treatment
Review
Share
Back to top