IMR Press / FBE / Volume 4 / Issue 7 / DOI: 10.2741/E572

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Use of BMPs and bisphosphonates to improve bone fracture healing

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1 Department of Orthopaedic Research & Biotechnology, The Children’s Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia
2 Discipline of Paediatrics and Child Health, Faculty of Medicine, A27 University of Sydney, NSW 2006, Australia
3 School of Aerospace, Mechanical and Mechatronic Engineering, J07 University of Sydney, NSW 2006, Australia
4 Department of Orthopedics, Lund University Hospital, SE-221 85 Lund, Sweden

*Author to whom correspondence should be addressed.


Front. Biosci. (Elite Ed) 2012, 4(7), 2647–2653;
Published: 1 June 2012

In orthopaedics, focus is often placed on increasing bone formation by an anabolic drug like the recombinant human bone morphogenetic protein (rhBMP). However, premature or excessive bone resorption, due to stress-shielding, instability or infection/inflammation can lead to poor, delayed, or absent bone union. Anti-catabolic drugs such as bisphosphonates have therefore been explored to improve bone repair. This short review discusses the current literature underlying the anaboliccatabolic paradigm for bone repair with a focus on BMP and bisphosphonate combination approaches.

Bone tissue engineering
Bone morphogenetic protein (BMP)
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