IMR Press / FBE / Volume 4 / Issue 7 / DOI: 10.2741/E571

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Role of toll like receptors in the antibody response to encapsulated bacteria

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1 The Floating Hospital for Children at Tufts Medical Center and The Department of Pediatrics, Tufts University School of Medicine, Boston Massachusetts 02111, USA

*Author to whom correspondence should be addressed.

Academic Editor: Isabelle Bekeredjian-Ding

Front. Biosci. (Elite Ed) 2012, 4(7), 2638–2646; https://doi.org/10.2741/E571
Published: 1 June 2012
(This article belongs to the Special Issue Exploiting toll-like receptors to interfere with the B cell response)
Abstract

Encapsulated bacteria are major pathogens in humans. The capsular polysaccharides (PS) of these bacteria are T-independent type 2 antigens, are not processed by antigen presenting cells and do not induce T cell help. PS antigens are poor immunogens in children less than two years, the peak age incidence of encapsulated bacterial infection. The TNF family receptors BAFFR and TACI interaction with the cytokines BAFF and APRIL are essential co-stimulatory factors for humoral responses to PS. Linkage of PS to a carrier protein to make glycoconjugate vaccines, enhances the immune response to PS similar to a T cell dependent antigen. Multiple doses of glycoconjugate vaccines are required to elicit protection, making their use in the developing world problematic. TLR engagement augments BAFF mediated PS antibody responses and TLR ligands serve as adjuvants for induction of anti-PS antibodies either for pure PS or for PS-protein conjugate vaccines. A variety of TLR ligands stimulate increased production of antibodies directed to both PS and protein components of encapsulated bacteria, and glycoconjugate vaccines, suggesting their future role in immunization strategies.

Keywords
Toll like receptors
Polysaccharide capsules
Antibodies
T-independent antigens
Glycoconjugate vaccines
Review
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