IMR Press / FBE / Volume 4 / Issue 7 / DOI: 10.2741/E564

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Igf1r is not required for AIB1-induced mammary hyperplasia and ductal branching

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1 Laboratory of Cellular and Molecular Biology, Centro de Investigacion Principe Felipe, CIPF, Autopista del Saler, 16, 46013 Valencia, Spain
2 Department of Mouse Genetics and Metabolism, Center of Molecular Medicine, University of Cologne, Cologne, Germany

*Author to whom correspondence should be addressed.

Academic Editor: Vicente Andres

Front. Biosci. (Elite Ed) 2012, 4(7), 2536–2545; https://doi.org/10.2741/E564
Published: 1 June 2012
Abstract

The oncogene AIB1 (amplified in breast cancer 1) is a transcriptional coactivator which is up-regulated in many types of tumors including breast cancer. Studies with cell lines and animal models reveal that AIB1 interacts with the IGF-I signaling pathway at different molecular levels. To determine whether AIB1-dependent cell growth requires IGF-I signaling, we deleted the Igf1r gene specifically in the mammary gland of transgenic mice which overexpress AIB1 and are characterized by the development of epithelial hyperplasia, a pre-neoplastic change in breast tissue. Loss of Igf1r alone reduced cell proliferation, ductal branching and fat pad occupancy in comparison with wildtype glands. However, in the transgenic mice that overexpress moderate levels of AIB1, the absence of Igf1r had a minimal effect on epithelial hyperplasia and ductal branching in the mammary gland. Thus, our results confirm the essential role of Igf1r in mammary gland morphogenesis and demonstrate that overexpression of AIB1 circumvents the requirement for the Igf1r pathway in promoting epithelial growth during mammary development.

Keywords
AIB1
IGF-I
Igf1r
Mammary gland
Branching morphogenesis
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