IMR Press / FBE / Volume 4 / Issue 7 / DOI: 10.2741/E556

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

The role of micronutrients in the diet of HIV-1-infected individuals

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1 Department of Clinical and Molecular Biomedicine, Division of Infectious Diseases, University of Catania, Catania, Italy
2 Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, USA
3 Department of Pediatrics and Pediatric Neurology, Azienda Ospedaliera Universitaria OVE-Policlinico, University of Catania, Catania, Italy
4 Department of Medical Oncology, National Cancer Institute, Aviano, PN, Italy
5 Department of Biomedical Science, University of Catania, Via Androne 83, Catania, Italy
6 Institute of Food Science and Nutrition, Università Cattolica Sacro Cuore, Via Emilia Parmense 84, Piacenza, Italy

*Author to whom correspondence should be addressed.

Academic Editor: Fabio Galvano

Front. Biosci. (Elite Ed) 2012, 4(7), 2442–2456; https://doi.org/10.2741/E556
Published: 1 June 2012
(This article belongs to the Special Issue Dietary approaches to prevent chronic-degenerative diseases)
Abstract

Vitamins, zinc and selenium are important micronutrients that play crucial functions at the cellular and molecular level. Immune response of several different cell types can be modulated by these micronutrients. Deficiency in micronutrients has been extensively reported in HIV-1-infected individuals and further correlated with CD4+ T-cell count, HIV-1 plasma viral load, disease progression and mortality. Supplementation by micronutrients has had controversial effects. Thorough future investigations and trials are certainly needed to strategically plan evidence-based interventions. Here, we review the available data on use of micronutrients during the course of HIV-1 infection.

Keywords
HIV
Diet
Vitamins
Anti-oxidants
Zinc
Selenium
Review
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