IMR Press / FBE / Volume 4 / Issue 7 / DOI: 10.2741/E544

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

High sensitive troponin T in individuals with chest pain of presumed ischemic origin

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1 Laboratory of Clinical Biochemistry and Molecular Biology, Fondazione, T. Campanella, University of Magna Graecia, Catanzaro, Italy
2 Laboratory of Bioinformatics, University of Magna Graecia, Catanzaro, Italy
3 Division of Cardiology, University of Magna Graecia, Catanzaro, Italy
4 Division of Forensic Medicine, University of Magna Graecia, Catanzaro, Italy

*Author to whom correspondence should be addressed.

Academic Editor: Giovanni Li Volti

Front. Biosci. (Elite Ed) 2012, 4(7), 2322–2327; https://doi.org/10.2741/E544
Published: 1 June 2012
(This article belongs to the Special Issue Biochemical markers in biological fluids)
Abstract

This study was aimed at assessing the bias of high sensitive cardiac troponin T vs. the standard cardiac troponin T in a selected population with chest pain of presumed cardiac origin. Serum cTnT was determined in 132 patients and in 106 apparently healthy controls by both assays. The hs-cTnT outperformed the standard generation assay by: i) allowing a larger and earlier diagnosis of AMI (74.2% vs. 64.3% patients resulted positive at the final diagnosis of AMI when tested with the hs-cTnT or the stdcTnT assay, respectively); ii) showing a better timedependent dynamics in patients with AMI due to a higher precision at low concentrations; iii) identifying, within the controls, 6 subjects in whom a further examination revealed the presence of chronic asymptomatic cardiac ischemia. The results underscore the excellent performance of the hscTnT assay in our population. The use of this test can thus be strongly recommended in subjects presenting to the emergency unit with chest pain of presumed ischemic origin in order to increase the probability of earlier diagnosis of AMI, especially in non-STEMI.

Keywords
Cardiac troponin T
Acute myocardial infarction
Coronary artery disease
Early diagnosis
Biomarkers
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