IMR Press / FBE / Volume 4 / Issue 3 / DOI: 10.2741/E437

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Influence of lifestyle habits, nutritional status and insulin resistance in NAFLD

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1 Sport Centre, University of Modena and Reggio Emilia, Modena, Italy
2 Liver Centre, Azienda USL di Modena, Gastroenterologia Ospedale, Ramazzini, Carpi, Modena, Italy
3 Integrated Department of Laboratory Diagnostic and Legal Medicine, Modena and Reggio Emilia University, Italy

*Author to whom correspondence should be addressed.

Academic Editor: Fabio Galvano

Front. Biosci. (Elite Ed) 2012, 4(3), 1015–1023;
Published: 1 January 2012
(This article belongs to the Special Issue Dietary approaches to prevent chronic-degenerative diseases)

Non alcoholic fatty liver disease (NAFLD) is associated with obesity, diabetes and insulin resistance (IR). The aim of our study was to assess the relationship between IR, anthropometry, lifestyle habits, resting energy expenditure (REE) and degree of fatty liver at ultrasound in 48 overweight patients with NAFLD as compared to 24 controls without fatty liver, matched for age. Nutritional status, alcohol intake and physical activity were assessed by skinfold thickness measurements, a 7-day diary, and SenseWear armband (SWA). REE was assessed by both SWA (REE-SWA) and a Vmax metabolic cart (REEVmax). Fatty liver was measured by US and the Doppler Power Index was calculated. IR was assessed using the HOMA index. There was significant correlation between waist circumference, HOMA, Doppler power index and fatty liver grade at US. Multivariate analysis showed that alteration of waist circumference, Doppler power index, and HOMA were the major significant predictors of fatty liver. Our data demonstrated a significant association between NAFLD and central adiposity and IR.

Resting Energy Expenditure
SenseWear armband
Doppler Power Index
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