IMR Press / FBE / Volume 4 / Issue 3 / DOI: 10.2741/E431

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Genetic and epigenetic signatures of breast cancer subtypes

Show Less
1 Department of Pathology and Laboratory Medicine and The University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS

*Author to whom correspondence should be addressed.

Academic Editor: Raghunath Chatterjee

Front. Biosci. (Elite Ed) 2012, 4(3), 934–949; https://doi.org/10.2741/E431
Published: 1 January 2012
(This article belongs to the Special Issue Epigenetics, non-coding RNAs and gene regulation)
Abstract

Breast cancer is a heterogeneous disease at both the histological and molecular levels. The current model of breast tumorigenesis suggests that the normal mammary stem cell and the various progenitors that arise thereof can be transformed and generate lineage-restricted tumor phenotypes. This model is supported by observations that the different subtypes of breast cancer share transcriptional signatures intrinsic to normal components of the mammary epithelium. Studies have since elaborated these molecular signatures to include recurrent genetic abnormalities, patterns of DNA methylation and dysregulation of microRNAs. Here we aim to review the current state of knowledge concerning the cellular etiology of breast cancer subtypes and the genetic, transcriptional and epigenetic aberrations associated with each subtype.

Keywords
Breast Cancer
Cancer Stem Cell
BRCA1
Epigenetics
Basal-Like Breast Cancer
Triple Negative Breast Cancer
DCIS
miRNA
Review
Share
Back to top