IMR Press / FBE / Volume 4 / Issue 3 / DOI: 10.2741/E421

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Therapeutic effect of near infrared (NIR) light on Parkinson’s disease models

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1 Department of Neurology, Medical College of Wisconsin, 8701 W. Watertown Plank Rd, Milwaukee, WI, 53226, USA
2 Department of Health Sciences, University of Wisconsin-Milwaukee, 2400 E. Hartford Ave, Milwaukee, WI, 53201, USA
3 The Hamner-UNC Institute for Drug Safety Sciences, The Hamner Institutes for Health Sciences, Six Davis Drive, Research Triangle Park, NC, 27709, USA
4 Marshfield Clinic Research Foundation, (MCRF) 1000 N. Oak Ave., Laird South-ML1 Marshfield, WI 54449
5 Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 W. Watertown Plank Rd, Milwaukee, WI, 53226, USA

*Author to whom correspondence should be addressed.

Academic Editor: Albert Y. Sun

Front. Biosci. (Elite Ed) 2012, 4(3), 818–823; https://doi.org/10.2741/E421
Published: 1 January 2012
Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder that affects large numbers of people, particularly those of a more advanced age. Mitochondrial dysfunction plays a central role in PD, especially in the electron transport chain. This mitochondrial role allows the use of inhibitors of complex I and IV in PD models, and enhancers of complex IV activity, such as NIR light, to be used as possible therapy. PD models fall into two main categories; cell cultures and animal models. In cell cultures, primary neurons, mutant neuroblastoma cells, and cell cybrids have been studied in conjunction with NIR light. Primary neurons show protection or recovery of function and morphology by NIR light after toxic insult. Neuroblastoma cells, with a gene for mutant alphasynuclein, show similar results. Cell cybrids, containing mtDNA from PD patients, show restoration of mitochondrial transport and complex I and IV assembly. Animal models include toxin-insulted mice, and alphasynuclein transgenic mice. Functional recovery of the animals, chemical and histological evidence, and delayed disease progression show the potential of NIR light in treating Parkinson’s disease.

Keywords
Parkinson’s Disease
Near Infrared Radiation
NIR light
Cytochrome C Oxidase
Complex I
complex IV
Light Therapy
Electron Transport Chain
MPTP
MPP+ : 1- Methyl-4-Phenylpyridinium
LED: light emitting diode
Review
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