IMR Press / FBE / Volume 3 / Issue 4 / DOI: 10.2741/E327

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Involvement of LOC66273 isoform 2, a novel Mth938 containing protein, in MAPK pathway
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1 State Key Laboratory of Animal Nutrition, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China
2 Human Disease Genomics Center, Peking University, No. 38 Xueyuan Road, Beijing 100191, China

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2011, 3(4), 1241–1248;
Published: 1 June 2011

Using dual-luciferase reporter assay system, our previous study showed that LI2, significantly increased AP-1 transcriptional activity. Sub-cellular localization showed that GFP-LI2 fusion protein is diffusely distributed in the cytoplasm, with some highly concentrated spots around the nucleus, suggesting that LI2 protein has a physiological role in cytoplasm. Overexpression of LI2 significantly increased AP-1 transcriptional activity. Moreover, LI2 significantly promoted transcriptional activity of Elk1 and c-jun, which might, at least partly, be associated with activated ERK1/2 and JNK/SAPK signaling pathway. These data suggest that LI2 is a novel MAPK regulating protein.

LOC66273 isoform 2
AP-1 transcriptional activity
MAPK pathway
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