IMR Press / FBE / Volume 3 / Issue 4 / DOI: 10.2741/E323

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Asthma treatment through the beta receptor: lessons from animal models
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1 Vermont Lung Center, College of Medicine, University of Vermont, Burlington, VT

*Author to whom correspondence should be addressed.

Academic Editor: Reynold Panettieri

Front. Biosci. (Elite Ed) 2011, 3(4), 1201–1208; https://doi.org/10.2741/E323
Published: 1 June 2011
(This article belongs to the Special Issue Beta2 agonists in airways disease: molecules to medicine)
Abstract

Asthma is a significant health problem worldwide with a prevalence that continues to rise and for which there is no cure. Animal models have been used for decades to investigate the cause and cures of asthma, and while they do not always mimic many of the facets of this syndrome, mechanistic animal studies are still nevertheless very useful. Animal studies with beta-agonists suggest much broader and perhaps more important roles for beta-agonists since beta-agonists reduce aspects of inflammation and may affect structural remodeling. Studies using enantiomers of beta-agonists provide a confusing picture of the degree and mechanism of the deleterious effects of racemic mixtures and/or the S-enantiomer or other classes of beta-agonists. Neural mechanisms are implicated. The future holds a promise of even more insight into the mechanisms of the acute and chronic role of the beta-adrenoceptor, asthma therapeutics, in particular, beta-agonists that will lead to a better understanding of the pathogenesis and treatment of asthma.

Keywords
Asthma
animal models
inflammation
cytokines
airways
hyperresponsiveness
beta-agonists
review
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