IMR Press / FBE / Volume 3 / Issue 3 / DOI: 10.2741/E321

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Prognostic value of H-MLH1 after adjusting for RPA class in GBM patients
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1 Intermountain Medical Center, 5171 South Cottonwood Street, Neuroscience Center, Suite 810, Murray, Utah 84107
2 Radiation Therapy Oncology Group, American College of Radiology, 1818 Market Street, Suite 1600, Philadelphia, Pa. 19103- 3604
3 Department of Radiation Oncology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226
4 SUNY, 339 Hicks Str, Brooklyn, N.Y. 11201
5 University of Wisconsin, Human Oncology/Radiation Oncology, 600 Highland Avenue K4/310-3684, Madison, WI 53792
6 Emory University School of Medicine, Radiation Oncology, 1365 Clifton Road NE Rm. A1316, Atlanta, GA 30322

*Author to whom correspondence should be addressed.

Academic Editor:Mukesh Agarwal

Front. Biosci. (Elite Ed) 2011, 3(3), 1182–1191; https://doi.org/10.2741/E321
Published: 1 June 2011
(This article belongs to the Special Issue Novel strategies for detection, prevention and treatment of cancer)
Abstract

Repair of DNA adducts appears to be an important mechanism in chemotherapy responsiveness in glioblastoma multiforme (GBM). Meta-analyses have suggested that the addition of chemotherapy increases the percentage of long-term survivors. Because GBM is characterized by multiplicity of pathways that characterize growth and treatment resistance, we hypothesized probing a multiplicity of repair factors may be able to identify more than one prognostic factor that may be utilized in molecularly targeted therapy that might improve survival and QOL. Seven DNA repair factors showed statistical significance when added to the initial logistic model of RPA class on length of survival status. After adjusting for RPA class the only statistically significant result of the multivariable logistic regressions for these 7 DNA repair factors was that as hMLH1-MF1 increased, the odds of being a short-term survivor versus a long-term survivor decreased (OR: 0.913, 95% CI: 0.838-0.995, p=0.0385), multivariable analysis showed no associations between survival status and MGMT and p53 status, and the only statistically significant prognostic DNA repair factor was human Mut L Homologue 1 (hMLH1).

Keywords
GBM
DNA repair factors
hMLH1
RPA Class
Long-Term Survivor
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