IMR Press / FBE / Volume 3 / Issue 3 / DOI: 10.2741/E318

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

TRAIL effect on osteoclast formation in physiological and pathological conditions
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1 Department of Human Anatomy and Histology, University of Bari, Italy
2 Department of Biomedical Science, University of Foggia, Italy
3 Division of Endocrinology, Università Campus Bio-Medico, Rome, Italy
4 Hematology Section, Department of Pathology, University of Bari, Italy
5 Department of Oral Science, Section of Oral Surgery, University of Bari, Italy

*Author to whom correspondence should be addressed.


Front. Biosci. (Elite Ed) 2011, 3(3), 1154–1161;
Published: 1 June 2011

Although osteoclasts (OCs) differentiate under the control of RANK/RANKL/OPG system, a number of inflammatory cytokines can contribute to increase osteoclastogenesis in diseases associated with bone loss. Recently, different studies indicate that TRAIL is implicated in modulating osteoclastogenesis. Here, we investigated the effect of TRAIL on OC formation in physiological and pathological conditions with bone involvement utilizing osteoclastogenesis in vitro models represented by peripheral blood mononuclear cells (PBMCs) from healthy donors and patients affected by multiple myeloma or periodontal disease. We demonstrated that in PBMCs from healthy donors TRAIL can directly induce OC formation in the absence of RANKL, while exert an inhibitory effect when added concomitantly to RANKL. In PBMCs from the patients, in which media the levels of TRAIL, RANKL and OPG are elevated, the neutralization of TRAIL partially inhibits the OC formation, and this effect was reversed by RANKL addition. Finally, we detect high TRAIL levels in the sera from the patients. In conclusion, our results indicate that TRAIL could exert a different role in modulating OC differentiation in physiological and pathological conditions.

Periodontal Disease
Multiple Myeloma
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