IMR Press / FBE / Volume 3 / Issue 3 / DOI: 10.2741/E317

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
DNA microarray analysis in endometriosis for development of more effective targeted therapies
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1 Centre Hospitalier Universitaire de Clermont-Ferrand, Chirurgie Gynecologique, 1, Place Lucie Aubrac, 63003 ClermontFerrand Cedex 1, France
2 Universite d’Auvergne Clermont I, Centre d'Endoscopie et des Nouvelles Techniques Interventionnelles (CENTI), 2ETG Bâtiment 3C, 28, Place Henri Dunan, 63000 Clermont-Ferrand

*Author to whom correspondence should be addressed.

Academic Editor: Khaleque Newaz Khan

Front. Biosci. (Elite Ed) 2011, 3(3), 1139–1153; https://doi.org/10.2741/E317
Published: 1 June 2011
(This article belongs to the Special Issue Frontiers in endometriosis)
Abstract

Microarray technology has become a widely used tool for analyzing the expression of tens of thousands of genes simultaneously on high-density microarrays in a single experiment, together with the availability of the complete nucleotide sequence of the human genome. DNA microarray technologies are powerful tools in the laboratory setting for scientific research, hypothesis generation, and the production of leads for subsequent validation through more sophisticated technologies. Since 2002, and particularly in the past few years, the utility of various DNA microarray technologies in endometriosis has rapidly and tremendously evolved; DNA microarray studies provide extremely important information that enable a better understanding of pathophysiology and disease etiology. This is a review of the literature focused on new findings of endometriosis pathophysiology obtained using various microarray technologies: gene expression profiling, microarray-based comparative genomic hybridization (CGH) (array CGH) single nucleotide polymorphism (SNP) arrays, the combination of chromatin immunoprecipitation (ChIP) with hybridization of microarrays (ChIP-on-chip). The present review discusses the results of a decade of DNA microarray technology experience, with emphasis on the pathophysiology of endometriosis in the context of clinical studies.

Keywords
DNA microarray
DNA Copy Number
Endometrioiss
Epigenetics
Gene Expression
Genome Wide Association Study
microRNA
Review
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