IMR Press / FBE / Volume 3 / Issue 3 / DOI: 10.2741/E304

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
B7-H3 and its relevance in cancer; immunological and non-immunological perspectives
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1 Oslo University Hospital, The Norwegian Radium Hospital, Department of Tumor Biology, P O Box 4953 Nydalen, NO-0424 Oslo, Norway

*Author to whom correspondence should be addressed.

Academic Editors: Wen G Jiang, Richard Ablin

Front. Biosci. (Elite Ed) 2011, 3(3), 989–993; https://doi.org/10.2741/E304
Published: 1 June 2011
(This article belongs to the Special Issue Bone metastasis, the molecular, cellular and clinical prospects)
Abstract

B7-H3 is a transmembrane glycoprotein and a member of the B7 family of proteins. It was previously known as an immunoregulatory molecule, shown in recent years to be of clinical significance in different types of cancer. In some tumor types high expression of B7-H3 has been linked to a poor prognosis, whereas in other cancers the opposite effect has been observed. Taken together, the precise role of B7-H3 in tumor immunity is unclear and further investigations are needed. Another aspect of B7-H3 that so far has received little interest is its role in non-immunological systems. We have demonstrated that knockdown of B7-H3 in melanoma and breast cancer cells results in both increased chemosensitivity to several different chemotherapeutic compounds and decreased metastatic potential. This has been observed in both in vitro and in vivo experiments. Several different signaling pathways seems to be involved, as B7-H3 knockdown can be linked to both higher expression of apoptotic markers and increased phosphorylation of Stat3. Increased knowledge of also the non-immunological role of B7-H3 protein is therefore of great biological and putative therapeutic interest.

Keywords
B7-H3
Chemosensitivity
Metastasis
Signaling Pathways
Review
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