IMR Press / FBE / Volume 3 / Issue 3 / DOI: 10.2741/E299

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Regenerative medicine and tissue engineering in orthopaedic surgery

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1 Department of Orthopedic Surgery, University Hospital, Sveti Duh, Zagreb, Croatia
2 Department of Biotechnology, University of Rijeka, Croatia
3 Department of Molecular Biology, Faculty of Science, University of Zagreb, Croatia
4 Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
5 Department of Orthopedic Surgery, Medical School University of Zagreb, Croatia

*Author to whom correspondence should be addressed.

Academic Editor: Nives Pecina-Slaus

Front. Biosci. (Elite Ed) 2011, 3(3), 923–944; https://doi.org/10.2741/E299
Published: 1 June 2011
(This article belongs to the Special Issue Biology of brain tumors)
Abstract

Orthopedic surgery is going through a serious paradigm shift; instead of simply replacing damaged tissues with prosthetic or allograft material, the aim is to regenerate them. This endeavor has generated the field of regenerative orthopaedics, an increasingly expanding area of research with hopes of providing new and better treatments for diseases and injuries affecting the musculoskeletal system. As part of this process, we are witnessing a substantial accumulation of new cellular and molecular insights into connective tissue function, coupled with emerging new concepts in stem cell biology and scaffolding technologies. Indeed, any successful strategy to regenerate musculoskeletal tissues can be portrayed as an intricate interplay between the three main constituents of the regenerative system: cells, environment and scaffolds. This review is not meant to be exhaustive and comprehensive, but aims to highlight concepts and key advances in the field of regenerative orthopaedics and tissue engineering, as well as to present current possibilities for clinical translation.

Keywords
Regenerative medicine
Tissue engineering
Stem cells
Scaffolds
Orthopedic surgery
Mesenchymal stem cells
Cartilage
Bone
Review
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