IMR Press / FBE / Volume 3 / Issue 3 / DOI: 10.2741/E295

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Reference values of blood cell counts in the first days of life
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1 Clinical Pathology Laboratories, G. Gaslini Children’s Hospital, Genoa, Italy
2 Department of Maternal, Fetal and Neonatal Medicine G. Gaslini Children’s Hospital, Genoa, Italy
3 Laboratory of Clinical Biochemical Medicine, S. Martino, Genoa, Italy
4 Biometric Unit, Medi-Service srl, Genoa, Italy
5 Neonatal Clinical and Biochemical Italian Research Group from Italian Society of Clinical Biochemistry (SiBioC), and Italian Society of Neonatology (SIN)
6 Neonatal Intensive Care Unit University of Cagliari, Cagliari, Italy
7 Department of Maternal, Fetal, Neonatal and Reproductive Medicine University of Siena, Siena, Italy
8 Department of Maternal, Fetal and Neonatal Medicine University of Palermo, Palermo, Italy
9 Neonatal Intensive Care Unit Di Venere Hospital, Bari, Italy
10 Chair of Neonatog, University of Turin, Turin, Italy
11 Neonatal Intensive Care Unit C. Arrigo Children’s Hospital, Alessandria, Italy

*Author to whom correspondence should be addressed.


Front. Biosci. (Elite Ed) 2011, 3(3), 871–878;
Published: 1 June 2011

The lack of updated neonatal reference values for hematological parameters impacts significantly with clinical management of both healthy and sick newborns. The present pilot study was thus aimed at assessing updated hematological Italian reference values in late preterm and term newborns. From January 2004 to December 2008 hematological laboratory tests were performed in 1175 newborns (820 healthy and 355 sick controls) between 33-41 weeks of gestation, during the first four days after birth. Hematological parameters were sorted for gender and gestational age and statistically analyzed. No gender-related differences were observed at different weeks of gestation and no significant differences were found when study population was sub-grouped for late preterm and term newborns. During the first 4 days of life erythrocytes and platelets remained stable whilst white blood cell counts and differentials were significantly modified. This study shares updated reference values for hematological parameters in the early phases after birth and offers additional support for improving the management of sick infants.

Hematological Parameters
Reference Curve
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