IMR Press / FBE / Volume 3 / Issue 2 / DOI: 10.2741/E283

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Focal adhesion kinase signaling and function in pancreatic cancer
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1 Department of Surgery, University of Florida College of Medicine,1600 SW Archer Road, Box 100109, Gainesville Florida, 32610
2 Department of Medicine, University of Florida College of Medicine,1600 SW Archer Road, Box 100109, Gainesville Florida, 32610
3 Department of Molecular Genetics and Microbiology, University of Florida College of Medicine,1600 SW Archer Road, Box 100109, Gainesville Florida, 32610

*Author to whom correspondence should be addressed.

Academic Editor: Vita Golubovskaya

Front. Biosci. (Elite Ed) 2011, 3(2), 750–756; https://doi.org/10.2741/E283
Published: 1 January 2011
(This article belongs to the Special Issue FAK signaling)
Abstract

In the United States and the European Union, pancreatic cancer is the fourth leading cause of cancer death in both men and women. Chemotherapy and radiation therapy have had little impact on survival, prompting the National Cancer Institute to declare that survival for pancreatic cancer has remained unchanged for three decades and its treatment has consistently been identified as an area of unmet medical need. Clearly, additional agents are needed to improve outcomes in this aggressive disease. Clinicians must translate the available knowledge of the molecular basis of this disease into rationale and effective therapeutic strategies for treatment. Pancreatic cancer has been found to have several genetic alterations and is, in fact, one of the tumors with the highest number of genetic mutations of any solid malignancy. These mutations include activation of K-ras and inactivation of p53, p16, and DPC4. Other alterations include upregulation of angiogenic factors and matrix metalloproteinases, dysregulation of growth factor receptors, and cytoplasmic kinases including focal adhesion kinase (FAK) and Src. The role of FAK in the pathogenesis of pancreatic cancer is discussed below and efforts aimed at the development of inhibitors of FAK for this disease are reviewed.

Keywords
Pancreatic Cancer
Focal Adhesion Kinase
Review
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