IMR Press / FBE / Volume 3 / Issue 2 / DOI: 10.2741/E281

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Dentin: structure, composition and mineralization
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1 UMR-S 747, INSERM, Universite Paris Descartes, Paris, France. michel.goldberg@parisdescartes.fr

*Author to whom correspondence should be addressed.

Academic Editor: Ermanno Bonucci

Front. Biosci. (Elite Ed) 2011, 3(2), 711–735; https://doi.org/10.2741/E281
Published: 1 January 2011
(This article belongs to the Special Issue The biomineralization process: mechanism, problems, perspectives)
Abstract

We review firstly the specificities of the different types of dentin present in mammalian teeth. The outer layers include the mantle dentin, the Tomes' granular and the hyaline Hopewell-Smith's layers. Circumpulpal dentin forming the bulk of the tooth, comprises intertubular and peritubular dentin. In addition to physiological primary and secondary dentin formation, reactionary dentin is produced in response to pathological events. Secondly, we evaluate the role of odontoblasts in dentin formation, their implication in the synthesis and secretion of type I collagen fibrils and non-collagenous molecules. Thirdly, we study the composition and functions of dentin extracellular matrix (ECM) molecules implicated in dentinogenesis. As structural proteins they are mineralization promoters or inhibitors. They are also signaling molecules. Three different forms of dentinogenesis are identified: i) matrix vesicles are implicated in early dentin formation, ii) collagen and some proteoglycans are involved in the formation of predentin, further transformed into intertubular dentin, iii) the distal secretion of some non-collagenous ECM molecules and some serum proteins contribute to the formation of peritubular dentin.

Keywords
Orthodentin
Mantle Dentin
Circumpulpal Dentin
Intertubular Dentin
Peritubular Dentin
Odontoblast
Pulp
SIBLINGs
SLRPs
Phospholipids
Dentin Mineralization
Review
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