IMR Press / FBE / Volume 3 / Issue 2 / DOI: 10.2741/E276

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Alternatives to heart transplantation: integration of biology with surgery
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1 Department of Cardiovascular Surgery, Marques de Valdecilla University Hospital, Santander, Spain
2 Department of Cardiac Surgery. Peron Hospital. Avellaneda, Argentina
3 Department of Cardiovascular Surgery, Pompidou Hospital, University Paris Descartes, France

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2011, 3(2), 635–647;
Published: 1 January 2011

Chronic heart failure is one of the major health care issues in terms of increasing number of patients, rate of hospitalizations and costs. Heart transplantation is the best established therapy for patients with severe heart failure. However, the number of donors limits the activity to 5000 heart transplants performed annually worldwide. This limitation has generated alternative treatments. The increase of the interest in the reversibility of the heart failure and the application of new biological alternatives has generated therapeutic strategies designed to integrate biology and medical technologies in order to act to the biomechanical, the molecular and the neurohormonal mechanisms of heart failure. These treatments include cellular cardiomyoplasty, tissue engineering, surgical left ventricular restoration as well as passive and active mechanical ventricular assistance as destination therapy, bridge to recovery or bridge to transplantation. The integrated development of these approaches could offer hopeful treatments, although there is still much to be learned regarding the optimal use of these strategies.

Heart failure
Heart transplantation
Stem cell therapy
Tissue engineering
Left ventricular restoration
Ventricular assist devices
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