IMR Press / FBE / Volume 3 / Issue 2 / DOI: 10.2741/E273

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Sevoflurane preconditioning confers neuroprotection via anti-inflammatory effects

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1 State Key Laboratory of Medical Neurobiology and Department of Anesthesiology of Huashan Hospital, Fudan University, 138 Yixueyuan Road, Shanghai, China, 200032
2 Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261

*Author to whom correspondence should be addressed,

Academic Editor: Feng Zhang

Front. Biosci. (Elite Ed) 2011, 3(2), 604–615; https://doi.org/10.2741/E273
Published: 1 January 2011
Abstract

Neuroprotection afforded by volatile anesthetic preconditioning (APC) has been demonstrated in both in vivo and in vitro experiments, yet the underlying mechanism is poorly understood. We therefore investigated whether suppression of p38 MAPK, NF-kappa B and the downstream pro-inflammatory signaling cascade contribute to sevoflurane APC-induced neuroprotection. Male Sprague-Dawley rats were exposed for 30min/day on 4 consecutive days to ambient air or to sevoflurane (1.2% or 2.4%). Then rats were subjected to filament occlusion of the middle cerebral artery (MCAO) for 60 min, and euthanized 3 days after MCAO for measuring infarct volume. APC with sevoflurane markedly improved neurological performance of stroke rats, significantly decreased infarct volume, and robustly suppressed activation of NF-kappa B and p38 MAPK, and expression of inflammatory cytokines. Furthermore, APC with sevoflurane showed a direct inflammation-suppressing effect in rat brain receiving intracerebroventricular infusion of a dose of LPS that doesn't cause overt brain damage. Thus, the data suggest that APC with sevoflurane confers neuroprotection against focal ischemic brain injury, at least in part, by the anti-inflammatory effects of sevoflurane.

Keywords
Cerebral Ischemia
Volatile Anesthetic Preconditioning
Sevoflurane
Neuroprotection
Nuclear Factor Kappa B
Inflammation
Inducible NO synthase
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