IMR Press / FBE / Volume 3 / Issue 2 / DOI: 10.2741/E267

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Risk of carcinoma in women with ovarian endometrioma
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1 Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan

*Author to whom correspondence should be addressed,

Academic Editor: Khaleque Newaz Khan

Front. Biosci. (Elite Ed) 2011, 3(2), 529–539; https://doi.org/10.2741/E267
Published: 1 January 2011
(This article belongs to the Special Issue Frontiers in endometriosis)
Abstract

Endometriosis affects an estimated 10% of women in the reproductive-age group. Here, we review current knowledge on molecular genesis of endometriosis-associated epithelial ovarian carcinoma (EOC). This article reviews the English language literature for biology, pathogenesis, and pathophysiological studies on endometriosis-associated EOC. Although endometriosis generally remains a benign condition, it demonstrates somatically acquired genetic alterations. Clear cell carcinoma (CCC) and endometrioid adenocarcinoma (EAC) are the most frequent types of EOC associated with endometriosis. Retrograde menstruation or ovarian hemorrhage carries highly pro-oxidant factors, such as iron, into the peritoneal cavity or ovarian endometrioma. CCC and EAC should be considered separately in studies of endometriosis-associated EOC. The repeated events of hemorrhage in endometriosis can contribute to carcinogenesis and progression via 3 major processes: 1) increasing oxidative stress promotes DNA methylation; 2) activating anti-apoptotic pathways supports tumor promotion; and 3) aberrant expression of stress signaling pathways contributes to tumor progression. This review summarizes recent advances in the understanding of epidemiology, carcinogenesis, pathogenesis, and pathophysiology of endometriosis-associated EOC; and a possible novel model is proposed.

Keywords
Endometriosis
Epithelial ovarian carcinoma
Clear cell carcinoma
Stress signaling
Molecular genetics
Review
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