IMR Press / FBE / Volume 3 / Issue 2 / DOI: 10.2741/E257

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

MYCN, neuroblastoma and focal adhesion kinase (FAK)

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*Author to whom correspondence should be addressed,

Academic Editor: Vita M. Golubovskaya

Front. Biosci. (Elite Ed) 2011, 3(2), 421–433; https://doi.org/10.2741/E257
Published: 1 January 2011
(This article belongs to the Special Issue Focal adhesion signaling in cancer)
Abstract

Neuroblastoma is the most common extracranial solid tumor of childhood. This tumor is characterized by poor survival, especially when it features amplification of the MYCN oncogene. The ability for human cancers to propagate is marked by their ability to invade and metastasize to distant sites. Focal adhesion kinase (FAK) is a key tyrosine kinase involved in the survival and metastasis of a number of human tumor types. We have shown that FAK is present in human neuroblastoma and that its expression in neuroblastoma is related to the MYCN oncogene. We have also demonstrated that inhibition of FAK in neuroblastoma leads to decreased tumor cell survival. The current review addresses the relationship between the MYCN oncogene, focal adhesion kinase and neuroblastoma.

Keywords
MYCN
neuroblastoma
FAK
Pediatric
SHEP-21/N
SK-N-AS
SK-N-BE(2)
Review
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