IMR Press / FBE / Volume 3 / Issue 1 / DOI: 10.2741/E248

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The effect of coptis chinensis on the signaling network in the squamous carcinoma cells
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1 Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, China
2 Suzhou Jiulong Hospital, Shanghai Jiaotong University School of Medicine, China
3 Mount Sinai School of Medicine, New York University, USA

*Author to whom correspondence should be addressed.

Academic Editor: Xueji Zhang

Front. Biosci. (Elite Ed) 2011, 3(1), 326–340; https://doi.org/10.2741/E248
Published: 1 January 2011
(This article belongs to the Special Issue Biosensors and their applications)
Abstract

The effects of Coptis chinensis on the behavior of squamous cell carcinoma have not yet been established. We examined the anticancer activity of Coptis chinensis on human squamous carcinoma cells, both in vitro and in xenografted nude mice, and applied Pathway Array Technology to understand possible involvement of signaling pathways in Coptis Chinensis induced tumor cells inhibition as well. Following Coptis chinensis treatment, a time-dependent reduction in proliferation was observed in both cell lines and NCR/NU mice. Coptis chinensis has a wide effect on cell signaling, including cell cycle regulation (Cdk6, Cdk4, cyclin B1, cyclin E, cyclin D1, p27), cell adhesion (E-cadherin, osteopontin), differentiation, apoptosis(p-Stat3, p53, BRCA1), cytoskeleton (p-PKC α/βII, Vimentin, p-PKCα), MAPK signaling (raf-1, ERK1/2, p-p38, p-ERK), and the phosphatidylinositol 3-kinase signaling pathway (p-Akt, Akt, p-PTEN). In our conclusions, Coptis chinensis may be a novel therapeutic drug for squamous cell carcinoma.

Keywords
Coptis chinensis
Berberine
Signaling network
Chinese medicine
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