IMR Press / FBE / Volume 3 / Issue 1 / DOI: 10.2741/E244

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Surfactant proteins A and D in pregnancy and parturition
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1 National Institute for Research in Reproductive Health, Mumbai, India
2 University of Bristol, School of Clinical Sciences, Obstetrics and Gynaecology, Bristol, UK

*Author to whom correspondence should be addressed.

Academic Editor: Uday Kishore

Front. Biosci. (Elite Ed) 2011, 3(1), 291–300; https://doi.org/10.2741/E244
Published: 1 January 2011
(This article belongs to the Special Issue Pulmonary surfactant in human health and disease)
Abstract

Surfactant proteins A and D have extra-pulmonary expression at various mucosal sites including the reproductive tract. Reproductive tissues require a fine immune balance, strong enough to keep infection at a bay and at the same time, subtle enough to support an allogeneic fetus throughout the pregnancy. Roles of SP-A and SP-D have been studied in depth and include immunoregulatory function, besides strengthening the innate immune system against various pathogens in the lungs. Interestingly, levels of SP-A and SP-D in the amniotic fluid increase progressively in pregnancy. SP-A has been implicated in the induction of parturition. The present review elaborates the plausible roles of SP-A and SP-D in pregnancy maintenance and future applications.

Keywords
SP-A
SP-D
Pregnancy
Parturition
Immunoregulatory
Host-Defense
Intra-Amniotic Infection
Metalloproteinases
T helper cell
Review
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