IMR Press / FBE / Volume 3 / Issue 1 / DOI: 10.2741/E220

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Influence of tissue particles on Fas expression in idiopathic interstitial pneumonia
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1 Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi Gunma Japan
2 WHO Collaborating Center of Prevention and Control of Chronic Respiratory Diseases, Dokkyo University, (DU-WCC), Mibu Tochigi, Japan
3 Japan Atomic Energy Agency, Takasaki Advanced Radiation Research Institute, Takasaki, Gunma, Japan
4 Division of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
5 Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi Gunma, Japan
6 Gunma University Faculty of Health Science, Maebashi Gunma, Japan

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2011, 3(1), 65–73; https://doi.org/10.2741/E220
Published: 1 January 2011
Abstract

Idiopathic interstitial pneumonia (IIP) is a progressive fibrosing interstitial pneumonia of unknown etiology with a poor prognosis. The aim of this study is to prove the occurrence of particle deposition and particle-induced tissue damage in IIP by examining proapoptotic Fas expression with in-air microparticle induced X-ray emission (in-air micro-PIXE) analysis. A total of 21 patients were enrolled. Lung tissues from 12 IIP patients and nontumorous lung tissues from 9 lung cancer patients (as a control) were subjected to in-air micro-PIXE analysis. The distribution of particles in lung tissue was compared with the localization of Fas expression by immunohistochemistry. Silicon (Si) was identified in 58.3% of IIP samples and 44.4% of control samples. Iron (Fe) was identified 25% in IIP samples and 11.1% in control samples. The mean lung tissue content of Si and Fe relative to S did not differ between IIP and control patients. Only two IIP patients showed the co-localization of Si and Fe deposition with Fas expression. Adaptation of this method would contribute to assess the influence of particles on IIP.

Keywords
Idiopathic Interstitial Pneumonia
Idiopathic Pulmonary Fibrosis
Apoptosis
Fas
Environmental Particle
Occupational Exposure
In-Air Micro-PIXE analysis
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