IMR Press / FBE / Volume 3 / Issue 1 / DOI: 10.2741/E219

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Allergy in the tropics: the impact of cross-reactivity between mites and ascaris
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1 Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
2 Foundation for the Development of Medical and Biological Sciences, Fundemeb, Cartagena, Colombia

*Author to whom correspondence should be addressed.

Academic Editor: Ernesto Enrique

Front. Biosci. (Elite Ed) 2011, 3(1), 51–64; https://doi.org/10.2741/E219
Published: 1 January 2011
(This article belongs to the Special Issue New insights in diagnosis and treatment of allergic diseases)
Abstract

Allergic diseases and nematode infections such as ascariasis are important health problems in underdeveloped tropical countries. The co-exposure to Ascaris lumbricoides and the domestic mites Blomia tropicalis and Dermatophagoides pteronyssinus induces a strong Th2 and immunomodulatory responses that can modify the natural history of both diseases. An associate phenomenon of these particular environmental conditions is cross reactivity between mite and Ascaris allergens. We demonstrated a high IgE cross reactivity between the allergenic extracts from both sources and that several already known allergens like tropomyosin and glutathione-s-tranferases are involved. Although this cross reactive antibody response has not been completely analyzed, there are clinical and experimental evidences suggesting that it could be an important component of the complex interactions between ascariasis and mite allergy. For example, it may affect the specificity of serological IgE tests for diagnosing both ascariasis and allergic diseases and, in consequence, the results of epidemiological surveys evaluating the predisposing or protecting role of ascariasis on allergy. In this review we discuss the potential role of cross reactivity on several aspects of allergy in the tropics that have been the matter of a number of investigations, some of them with controversial results.

Keywords
Cross Reactivity
Ascaris
Blomia Tropicalis
Dermatophagoides pteronyssinus
IgE
Allergens
Asthma
Diagnosis
Tropics
Review
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