IMR Press / FBE / Volume 3 / Issue 1 / DOI: 10.2741/E218

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Bioinformatics approach for the validation of non-small cell lung cancer biomarkers
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1 Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos 2600-anexo, Porto Alegre 90035-003, Brazil

*Author to whom correspondence should be addressed.

Academic Editor: Mauro Castro

Front. Biosci. (Elite Ed) 2011, 3(1), 46–50; https://doi.org/10.2741/E218
Published: 1 January 2011
(This article belongs to the Special Issue Gene networks, genome instability and evolutionary dynamics of cancer)
Abstract

Non-small cell lung cancer (NSCLC) accounts for nearly 1 million deaths annually, worldwide. Conventional treatments offer limited benefits and patients have a survival rate of approximately 1 year. A biomarker for NSCLC could provide the potential benefits of early diagnosis, prognosis and could lead to important applications such as drug targeting. In a search for a biomarker with prognostic value, we reviewed the literature and tested potential biomarkers by performing a meta-data analysis using public databank of NSCLC biopsies containing gene expression data and clinical and pathologic information from 111 patients. We generated standard Kaplan–Meier mortality curves by clustering patients according to either biomarker expression levels or NSCLC stage grouping. Our statistical analyses show that all 60 potential biomarkers analyzed here have no prognostic value for NSCLC patient outcome.

Keywords
Bioinformatic approach
Non-Small Cell Lung Cancer
prognostic biomarkers
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