IMR Press / FBE / Volume 3 / Issue 1 / DOI: 10.2741/E217

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Single nucleotide polymorphisms in IL-4Ra,IL-13 and STAT6 genes occurs in brain glioma

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1 State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, 200433, People's Republic of China
2 Neurosurgery Department of Huashan Hospital, Fudan University, Shanghai 200040, People ’s Republic of China
3 State Key Laboratory of Genetic Engineering and Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200433, People ’s Republic of China
4 Department of Neurosurgery, ChangZheng Hospital, Second Military Medical University, Shanghai Neurosurgical Institute, Shanghai 200003, People’s Republic of China
5 School of Life Science, East China Normal University, Shanghai 200062, People ’s Republic of China
6 Department of Toxicology, Shanghai Second Military Medical University, Shanghai, 200433, People ’s Republic of China

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2011, 3(1), 33–45; https://doi.org/10.2741/E217
Published: 1 January 2011
Abstract

Gliomas are aggressive brain tumor. Association studies were consistent for an inverse association between asthma and allergic conditions (IgE levels) and risk of glioma. Studies reported that the IL-4Ra, IL-13 and STAT6 genes played a relatively strong role in IgE production or allergy. This population-based case-control study aimed to find potential association between single nucleotide polymorphisms IL-13rs20541, IL-4Rars1801275 and glioma susceptibility in population, as well as STAT6 rs1059513 and STAT6 rs324015. Among non-smokers, homozygote GG of STAT6 4610A/G showed an increased association with risk of glioma compared with AA (adjusted OR=1.691, 95%CI=1.152-2.481, p=0.007, corrected p=0.028), and the haplotype with A allele at rs1059513 and G allele at rs324015 was revealed to increase glioma risk significantly (OR=1.321,95%CI= 1.081-1.614, p=0.007,corrected p=0.028). GG genotype of STAT6 4610A/G was a significant risk factor compared with AA in glioblastoma (adjusted OR=1.856, 95%CI=1.153-2.987, p=0.011, corrected p=0.044). GG of STAT6 4610A/G was significantly related to increased WHO IV risk compared with AA (adjusted OR=1.591,95%CI=1.030-2.459, p=0.036, corrected p=0.144). Interaction between IL-13 Arg130Gln and IL-4Ra Gln576Arg was observed in decreasing glioma risk (p=0.045).

Keywords
Glioma
single nucleotide polymorphism
IL-13
IL-4Ra
STAT6
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