IMR Press / FBE / Volume 2 / Issue 4 / DOI: 10.2741/E210

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Effects of epidural and systemic maternal analgesia in term infants: the NoPiL study
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1 Department of Surgical and Medical Critical Care, Section of Neonatology, University Hospital of Florence, Florence, Italy
2 Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena
3 Central Laboratory of Chemical-Clinical Analysis, Careggi University Hospital of Florence, Division of Anesthesiology
4 Careggi University Hospital of Florence, Italy
5 Division of Neonatology, “S. Giovanni di Dio” Hospital of Florence, Italy
6 Division of Anesthesiology, “S. Giovanni di Dio” Hospital of Florence, Italy
7 Department of Gynecology, Perinatology and Human Reproduction, University of Florence, Florence, Italy, Research Laboratory
8 Department of Cardiac Surgery, IRCCS San Donato Milanese, Italy
Academic Editor:Diego Gazzolo
Front. Biosci. (Elite Ed) 2010, 2(4), 1514–1519;
Published: 1 June 2010
(This article belongs to the Special Issue Clinical and biochemical markers and fetal-neonatal development)

The aim of the No Pain in Labour (NoPiL) study was evaluate the stress and clinical outcome of infants vaginally born without maternal analgesia and after maternal epidural or systemic analgesia. We studied 120 healthy term infants, 41 in the no analgesia group, 38 in the epidural analgesia group, and 41 in the systemic analgesia group. Cortisol, ß-endorphin, oxidative stress markers [ie: total hydroperoxide (TH) and advanced oxidation protein products (AOPP)], interleukin-1β (IL-1β), and interleukin-8 (IL-8) cytokines were measured in arterial cord blood samples. Infants in the 3 groups had similar Apgar score, cord blood pH and occurrence of hypoglycaemia, hyperbilirubinemia, and respiratory depression. Cortisol and endorphin plasma levels did not differ in the groups, nor did TH and AOPP values. IL-1β and IL-8 cytokine were higher in infants born after maternal epidural analgesia than in other groups. Short-term outcome and stress were similar in infants vaginally born without maternal analgesia and after epidural and systemic analgesia. The possible implications of the highest interleukin levels in the epidural analgesia group deserve further study.

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