IMR Press / FBE / Volume 2 / Issue 4 / DOI: 10.2741/E203

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Role of PUFA, the precursors of endocannabinoids, in human obesity and type 2 diabetes

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1 Instituto de Biologia Celular y I Catedra de Biologia Celular, Histologia y Embriologia, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Barros esquina Gordillo, Cordoba (5000), Argentina
2 CONICET, Argentina, Jawaharlal Nehru Technological University, Kakinada-533 003, India
3 Jawaharlal Nehru Technological University, Kakinada-533 003, India
Academic Editor:Undurti N. Das
Front. Biosci. (Elite Ed) 2010, 2(4), 1432–1447; https://doi.org/10.2741/E203
Published: 1 June 2010
(This article belongs to the Special Issue Advances in metabolic syndrome and diabetes mellitus)
Abstract

Polyunsaturated fatty acids (PUFAs) serve as precursors of the endocannabinoids (ECs) that are bioactive lipids molecules. Recent studies revealed that ECs participate in several physiological and pathological processes including obesity and type 2 diabetes mellitus. Here we review the experimental and clinical aspects of the role of endocannabinoids in obesity and type 2 diabetes mellitus and the modification of the endocannabinoids by exogenously administered PUFAs. Based on these evidences, we propose that the endocannabinoid system (ECS) can be modulated by exogenous manipulation of PUFAs that could help in the prevention and management of human diseases such as obesity, metabolic syndrome and type 2 diabetes mellitus.

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