IMR Press / FBE / Volume 2 / Issue 4 / DOI: 10.2741/E188

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Pediatric HIV infection and bone health: an emerging challenge
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1 Stefano Mora, and Ilaria Zamproni, Laboratory of Pediatric Endocrinology and BoNetwork, Division of Metabolic and Cardiovascular Sciences, San Raffaele Scientific Institute, via Olgettina 60, 20132 Milan, Italy
2 Alessandra Vigano, Pediatric Infectivology Unit, Department of Pediatrics, L. Sacco Hospital, via G.B. Grassi 74, 20157 Milan, Italy
Academic Editor:Reina Armamento-Villareal
Front. Biosci. (Elite Ed) 2010, 2(4), 1265–1274; https://doi.org/10.2741/E188
Published: 1 June 2010
(This article belongs to the Special Issue Skeletal biology)
Abstract

The available data indicate that HIV-infected children and adolescents have reduced bone mass compared to healthy peers. The increased survival due to the control of HIV infection by potent antiretroviral treatment, exposes patients to the achievement of a reduced peak bone mass and to an increased fracture risk during adult life. Reduced bone mass in HIV-infected children is the result of altered bone metabolism, showing significantly increased bone resorption rate. Both infection per se and the use of certain antiretroviral compounds seem to contribute to the altered metabolism. Preventative measures to improve bone health are thus necessary in all young patients that exhibit low bone mass measurements and altered bone metabolism.

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