IMR Press / FBE / Volume 2 / Issue 4 / DOI: 10.2741/E180

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Functional characterization of the decoy peptide, R10PIFLKRMPSI19P

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1 Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
2 United Graduate School of Agricultural Science, Gifu University, Gifu, Japan
3 Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
4 Vanderbilt University School of Medicine, Nashville, TN 37232 USA
Academic Editor:Fumiaki Suzuki
Front. Biosci. (Elite Ed) 2010, 2(4), 1211–1217; https://doi.org/10.2741/E180
Published: 1 June 2010
(This article belongs to the Special Issue Handle region peptide and prorenin receptor)
Abstract

Decoy peptide (R10PIFLKRMPSI19P) showed its beneficial role in ameliorating the end-stage organ damage related disorders. Subsequently, in vivo and in vitro studies have been carried out to verify its effectiveness in several models using different experimental approaches. These studies with decoy peptide including the "handle" sequence have focused on the association of the (pro)renin receptor and prorenin in the pathogenesis of diabetes and hypertension. However, the function of (pro)renin receptor might be more complex than it was anticipated as it is not only distributed intracellularly and appeared on the cell membrane but also found in plasma. The decoy resembling the N-terminal sequence of prorenin has been useful in determining the structure-function relationship of prorenin and (P)RR. Therefore, this review tries to shed light on the use of decoy peptide in elucidating the functional properties of both prorenin and (pro)renin receptor by pointing out recent studies.

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