IMR Press / FBE / Volume 2 / Issue 4 / DOI: 10.2741/E179

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Induced endogenous autotoxicity in Camptotheca

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1 National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, TX 75962, USA
Academic Editor:Shiyou Li
Front. Biosci. (Elite Ed) 2010, 2(4), 1196–1210; https://doi.org/10.2741/E179
Published: 1 June 2010
(This article belongs to the Special Issue Endogenous autotoxicity in plants)
Abstract

Are plants always immune to their endogenous toxic secondary metabolites? Without disturbance, fast-growing Camptotheca plants can avoid poison by its endogenous camptothecin (DNA topoisomerase I inhibitor) at more than 10 times higher than the fatal concentration of exogenous application to the plant. Pruning has been long known to promote lateral growth; however, here we report that auxin-reducing pruning can induce endogenous autotoxicity in Camptotheca: dramatic deviations from normal morphogenesis, including serrated or lobed leaves, disturbed phyllotaxis, and fasciated stems. The abnormal morphogenesis appears correlatively with the elevated camptothecin contents following decapitation pruning. Plants resume their normal morphogenesis when camptothecin is reduced to natural levels after stress discontinuation. Exogenously applied auxin restores a dwarf mutant of high camptothecin yield to its parent type of lower yield, suggesting that auxin may be a triggering factor for the observed autotoxicity. Autotoxicity induced by endogenous compounds has not been reported before.

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