IMR Press / FBE / Volume 2 / Issue 3 / DOI: 10.2741/E176

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Telomere length and its associations with oxidized-LDL, carotid artery distensibility and smoking
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1 Department of Molecular and Cardiovascular Research, Laboratory of Hypertension, University of Leuven, Study Coordinating Centre, Leuven, Belgium
2 Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium
3 Department of Epidemiology, Maastricht University, Maastricht, The Netherlands
4 Cardiovascular Research Unit, Center for Experimental Surgery and Anesthesiology, University of Leuven, Leuven, Belgium
5 Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, Maastricht University, the Netherlands
6 Heymans Institute of Pharmacology, Ghent University, Gent, Belgium
7 The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
Front. Biosci. (Elite Ed) 2010, 2(3), 1164–1168;
Published: 1 June 2010

Oxidative stress is a key factor driving the aging of cells and arteries. Studies suggest that white blood cell (WBC) telomere length is an index of systemic aging. We, therefore, investigated the association between WBC telomere length and oxidized-LDL, and vascular aging, expressed by the distensibility of the carotid artery. We studied a random population sample of 216 non-smokers and 89, smokers. In all subjects, age and gender- adjusted telomere length was inversely correlated with plasma oxidized-LDL (regression coefficient = -0.656 kb/mg/dL; p=0.0006). Independent of gender, age and mean blood pressure, carotid distensibility increased with telomere length (2.33±1.18 10-3/kPa/kb; p=0.05) but decreased with higher plasma levels of oxidized LDL (-10.7±3.91 10-3/kPa/ mg/dL; p=0.006). Adjusted for gender and age, smokers' telomere length was shorter (6.72 vs 6.91 kb; p=0.014) and plasma oxidized-LDL level higher (0.52 vs 0.46 mg/dL; p=0.03) than in non-smokers. Higher level of oxidized-LDL, is associated with shorter WBC telomeres and increased stiffness of the carotid artery. Smoking is marked by increased oxidative stress in concert with shortened WBC telomere length.

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